Amphipilic compounds with neuroprotective properties

0533018 - ÚOCHB 2021 RIV eng P - Patent Document
Chodounská, Hana - Jahn, Ullrich - Kapras, Vojtěch - Kudová, Eva - Valeš, Karel - Vyklický ml., Ladislav
Amphipilic compounds with neuroprotective properties.
2020. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. - Fyziologický ústav AV ČR, v. v. i. Date of the patent acceptance: 30.06.2020. Patent Number: CA3013725
R&D Projects: GA TA ČR(CZ) TE01020028; GA ČR(CZ) GBP304/12/G069
Institutional support: RVO:61388963 ; RVO:67985823
Keywords : steroid * NMDA receptor * neuroprotective
OECD category: Organic chemistry
https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=CA&NR=3013725C&KC=C&FT=D&ND=4&date=20200630&DB=&locale=en_EP

The present invention provides amphiphilic compounds with tetradecahydrophenanthrene skeleton of general formula I, and their enantiomers, wherein R1, R2, 115, R4 and R5 are as defined herein, exhibiting neuroprotective effects, their use as medicaments for treating neuropsychiatric disorders associated with an imbalance in glutamatergic neurotransmitter system, such as ischemic damage of CNS, neurodegenerative changes and disorders of CNS, affective disorders, depression, post-traumatic stress disorder and diseases related to stress, anxiety, schizophrenia and psychotic disorders, pain , addiction, multiple sclerosis, epilepsy, glioma, and a pharmaceutical composition containing said compound.
Permanent Link: http://hdl.handle.net/11104/0311550