Substituted heteropentadieno-pyrrolopyrimidine ribonucleosides for therapeutic use

0532862 - ÚOCHB 2021 RIV eng P - Patent Document
Hocek, Michal - Tokarenko, Anna - Smolen, Sabina - Hajdúch, M. - Džubák, P.
Substituted heteropentadieno-pyrrolopyrimidine ribonucleosides for therapeutic use.
2020. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. - Univerzita Palackého v Olomouci. Date of the patent acceptance: 07.07.2020. Patent Number: CA3031049
R&D Projects: GA ČR(CZ) GA16-00178S; GA TA ČR(CZ) TE01020028
Institutional support: RVO:61388963
Keywords : nucleosides * cytostatics * deazapurines
OECD category: Medicinal chemistry
https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=CA&NR=3031049C&KC=C&FT=D&ND=4&date=20200707&DB=&locale=en_EP

Substituted heteropentadieno-pyrrolopyrimidine ribonucleosides of general formula (I), where R is selected from the group comprising furan-2-yl, furan-3-yl, benzofuran-2-yl, methylsulfanyl, methoxy, amino, dimethylamino, methyl or chloro, and pharmaceutically acceptable salt thereof, their optical isomers and mixtures of such optical isomers. Compounds according to the invention show strong cytostatic and cytotoxic effects on cell lines in a wide variety of diseases including tumors of various histogenic origin.
Permanent Link: http://hdl.handle.net/11104/0311279