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The ε-Al.sub.x./sub.Fe.sub.2-x./sub.O.sub.3./sub. nanomagnets as MRI contrast agents: Factors influencing transverse relaxivity

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    0532457 - FZÚ 2021 RIV NL eng J - Journal Article
    Kubíčková, Lenka - Kaman, Ondřej - Veverka, Pavel - Herynek, V. - Brázda, Petr - Vosmanská, M. - Kmječ, T. - Dvořák, P. - Kubániová, D. - Kohout, J.
    The ε-AlxFe2-xO3 nanomagnets as MRI contrast agents: Factors influencing transverse relaxivity.
    Colloids and Surfaces A-Physicochemical and Engineering Aspects. Roč. 589, Feb (2020), s. 1-11, č. článku 124423. ISSN 0927-7757. E-ISSN 1873-4359
    R&D Projects: GA ČR GA19-02584S; GA MŠk(CZ) EF16_019/0000760
    Grant - others: OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
    Institutional support: RVO:68378271
    Keywords : epsilon polymorph iron oxide * magnetic nanoparticles * core-shell nanoparticles * Mössbauer spectroscopy * relaxometry * magnetic resonance imaging
    OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
    Impact factor: 4.539, year: 2020
    Method of publishing: Limited access
    https://doi.org/10.1016/j.colsurfa.2020.124423

    Novel type of contrast agents based on non-superparamagnetic nanoparticles of aluminum-doped epsilon polymorph of Fe2O3 is suggested and used as a model system to elucidate the role of magnetic blocking and other factors in the transverse relaxation of water. Specifically, the dependence of the transverse relaxivity r2 on the magnetic field, temperature, magnetization, surface modification and thickness of silica coating is analyzed for the epsilon-AlxFe2-xO3 nanoparticles with x = 0.23 and the median size of 21 nm. Irreversible magnetization processes in aqueous suspension of coated clusters of magnetic crystallites resulted in the field dependence of r2. The temperature dependence of r2 was interpreted by the combination of two different regimes - motional averaging and static dephasing regimes. Moreover, the performance of the contrast agent was demonstrated not only in ultra-high-field MRI at 11.75 T but also by imaging in vivo on a mouse model at 1 T.
    Permanent Link: http://hdl.handle.net/11104/0310944

     
     
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