Intra-species differences in population size shape life history and genome evolution

0532191 - ÚBO 2021 RIV GB eng J - Journal Article
Willemsen, D. - Cui, R. - Reichard, Martin - Valenzano, D. R.
Intra-species differences in population size shape life history and genome evolution.
eLife. Roč. 9, September (2020), č. článku e55794. ISSN 2050-084X. E-ISSN 2050-084X
R&D Projects: GA ČR GA19-01781S
Institutional support: RVO:68081766
Keywords : aging * evolution * evolutionary biology * genetics * genomics * lifespan * nothobranchius furzeri * turquoise killifish
OECD category: Zoology
Impact factor: 8.146, year: 2020
Method of publishing: Open access
https://elifesciences.org/articles/55794

The evolutionary forces shaping life history divergence within species are largely unknown. Turquoise killifish display differences in lifespan among wild populations, representing an ideal natural experiment in evolution and diversification of life history. By combining genome sequencing and population genetics, we investigate the evolutionary forces shaping lifespan among wild turquoise killifish populations. We generate an improved reference genome assembly and identify genes under positive and purifying selection, as well as those evolving neutrally. Short-lived populations from the outer margin of the species range have small population size and accumulate deleterious mutations in genes significantly enriched in the WNT signaling pathway, neurodegeneration, cancer and the mTOR pathway. We propose that limited population size due to habitat fragmentation and repeated population bottlenecks, by increasing the genome-wide mutation load, exacerbates the effects of mutation accumulation and cumulatively contribute to the short adult lifespan.
Permanent Link: http://hdl.handle.net/11104/0310770