Breathborne Biomarkers and the Human Volatilome

0531444 - ÚFCH JH 2021 RIV US eng M - Monography Chapter
Smith, D. - Španěl, Patrik - Hanna, G. B. - Dweik, R.A.
Selected ion flow tube mass spectrometry.
Breathborne Biomarkers and the Human Volatilome. Cambridge: Elsevier, 2020 - (Beauchamp, J.; Davis, C.; Pleil, J.), s. 137-153. ISBN 978-0-12-819967-1
Institutional support: RVO:61388955
Keywords : SIFT-MS * single-breath metabolites * breath biomarkers
OECD category: Physical chemistry

Selected ion flow tube mass spectrometry (SIFT-MS) was first realized as a viable technique for the analysis of trace gases in ambient air in 1996 and its potential for direct online, real-time analysis became immediately obvious. Instrumental development has gone through several phases from a large laboratory-based device to the current mobile commercial analytical instruments. SIFT-MS can be exploited for real-time analysis of volatile trace gases of biological origin, especially in breath,1 but also in the headspace of biological fluids, particularly urine,2 and trace compounds emitted by mammalian cell3 and bacterial cultures4 of clinical significance. The earliest research using SIFT-MS for breath analysis and related topics has been reviewed elsewhere.5 This chapter briefly introduces the technique and then reviews the latest discoveries and developments in SIFT-MS research of clinical
relevance.
Permanent Link: http://hdl.handle.net/11104/0310109