Quantification of volatile metabolites in exhaled breath by selected ion flow tube mass spectrometry, SIFT-MS

0531420 - ÚFCH JH 2021 RIV NL eng J - Journal Article
Španěl, Patrik - Smith, D.
Quantification of volatile metabolites in exhaled breath by selected ion flow tube mass spectrometry, SIFT-MS.
Clinical mass spectrometry. Roč. 16, APR 2020 (2020), s. 18-24. ISSN 2376-9998. E-ISSN 2213-8005
Institutional support: RVO:61388955
Keywords : trace gas-analysis * total-body water * organic-compounds * healthy-volunteers * bowel-disease * reagent ions * online * headspace * series * h3o+ * sift-ms * Breath VOCs * Metabolites * Biomarkers
OECD category: Physical chemistry
Impact factor: 2.146, year: 2020
Method of publishing: Limited access

Selected ion flow tube mass spectrometry, SIFT-MS, is a non-separative method for direct quantitative analyses of volatile compounds, VOCs, in air and humid breath based on chemical ionization. Selected reagent ions, either H3O+, NO+ or O-2(+) (non-reactive with major components of air), ionize analyte molecules during a defined time in a flow tube by ion-molecule reactions thus producing analyte ions that are characteristic of the neutral analyte VOCs. Concentrations can be calculated in real-time from the ion count rates. Direct on-line analysis of single or multiple breath exhalations or off-line analysis of breath samples collected into bags can be performed. Several volatile breath metabolites have been quantified by SIFT-MS, including ammonia, acetone, hydrogen cyanide, alcohols, pentane, acetic acid, methane, and sulphur compounds. Their potential as biomarkers is discussed. (C) 2020 Published by Elsevier B.V. on behalf of The Association for Mass Spectrometry: Applications to the Clinical Lab (MSACL).
Permanent Link: http://hdl.handle.net/11104/0310084