Physical study of proton therapy at CANAM laboratory on medulloblastoma cell lines DAOY

0531352 - ÚJF 2021 RIV GB eng J - Journal Article
Torrisi, L. - Davídková, Marie - Cutroneo, Mariapompea - Torrisi, Alfio
Physical study of proton therapy at CANAM laboratory on medulloblastoma cell lines DAOY.
Radiation Effects and Defects in Solids. Roč. 175, 9-10 (2020), s. 863-878. ISSN 1042-0150. E-ISSN 1029-4953
R&D Projects: GA MŠMT LM2015056; GA ČR(CZ) GBP108/12/G108; GA ČR GA19-02482S; GA MŠMT EF16_013/0001812
Institutional support: RVO:61389005
Keywords : protontherapy * Bragg peak * medulloblastoma cell line DAOY * proton dose
OECD category: Radiology, nuclear medicine and medical imaging
Impact factor: 1.141, year: 2020
Method of publishing: Limited access
https://doi.org/10.1080/10420150.2020.1780592

2.0 MeV proton beam accelerated at Tandetron is extracted in air through a thin film and allowed to scatter to irradiate the cell culture attached to the polymeric base of a biological flask. The irradiated cells were human medulloblastoma cell line Daoy treated with and without 5 nm sized spherical gold nanoparticles. Proton doses from 0.5 to 1.5 Gy have been employed to irradiate the cultures and to investigate the role of the radiotherapy performed with and without the use of the gold nanoparticles. Results indicated that cell survival is significantly reduced to about 50% when the nanoparticles at a concentration of about 6 x 10(13)particles/ml are employed.
Permanent Link: http://hdl.handle.net/11104/0312132