Number of the records: 1
Radioprotective effect of Hydroxyl radical scavengers on prokaryotic and eukaryotic cells under various Gamma irradation conditions
- 1.0524442 - ÚJF 2021 RIV GB eng J - Journal Article
Ondrák, L. - Vachelová, Jana - Davídková, Marie - Neužilová, B. - Čuba, V. - Múčka, V.
Radioprotective effect of Hydroxyl radical scavengers on prokaryotic and eukaryotic cells under various Gamma irradation conditions.
Radiation Protection Dosimetry. Roč. 186, 2-3 (2019), s. 186-190. ISSN 0144-8420. E-ISSN 1742-3406
Institutional support: RVO:61389005
Keywords : deoxyribonucleic acid * DNA damage * stand breaks
OECD category: Biophysics
Impact factor: 0.773, year: 2019
Method of publishing: Limited access
https://doi.org/10.1093/rpd/ncz201
The influence of various hydroxyl radical scavengers such as methanol, ethanol and dimethyl sulfoxide on radiation sensitivity of prokaryotic cells (bacteria Escherichia coli) and eukaryotic cells (yeast Saccharomyces cerevisiae and V79 cells-Chinese hamster pulmonary fibroblasts) irradiated by Co-60 gamma radiation was investigated. The dependence of radiation sensitivity on dose rate in range from 1.8 to 100 Gy h(-1) was evaluated. Survival of cells irradiated by increasing dose rates was followed using clonogenic assay. Specific protective effect was found to be a nonmonotonous function of dose rate with typical maximum at the dose rate range from 50 to 55 Gy h(-1) in all studied cell types.
Permanent Link: http://hdl.handle.net/11104/0308803
Number of the records: 1