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Synthesis of new cisplatin derivatives from bile acids
- 1.0523952 - ÚEB 2021 RIV CH eng J - Journal Article
Seroka, B. - Łotowski, Z. - Hryniewicka, A. - Rárová, Lucie - Sicinski, R. R. - Tomkiel, A. M. - Morzycki, J.W.
Synthesis of new cisplatin derivatives from bile acids.
Molecules. Roč. 25, č. 3 (2020), č. článku 655. E-ISSN 1420-3049
Institutional support: RVO:61389030
Keywords : Bile acids * Cholic acid * Deoxycholic acid * Hyodeoxycholic acid * Lithocholic acid * Platinum(II) complexes * Steroidal diamines
OECD category: Organic chemistry
Impact factor: 4.412, year: 2020
Method of publishing: Open access
http://doi.org/10.3390/molecules25030655
A series of bile acid derived 1,2- and 1,3-diamines as well as their platinum(II) complexes were designed and synthesized in hope to get a highly cytotoxic compound by the combination of two bioactive moieties. All complexes obtained were subjected to cytotoxicity assays in vitro and some hybrid molecules showed an expected activity.
Permanent Link: http://hdl.handle.net/11104/0308262
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