Comparison of the radiation sensitivity of the breast cancer cell line MCF7 and human adipose-derived stem cells

0523901 - ÚJF 2021 RIV US eng J - Journal Article
Jelínek Michaelidesová, Anna - Vachelová, Jana - Cupal, Lukáš - Konířová, Jana - Pachnerová Brabcová, Kateřina - Bačáková, Lucie - Vandrovcová, Marta - Davídková, Marie
Comparison of the radiation sensitivity of the breast cancer cell line MCF7 and human adipose-derived stem cells.
Radiation Protection Dosimetry. Roč. 186, 2-3 (2019), s. 155-158. ISSN 0144-8420. E-ISSN 1742-3406
R&D Projects: GA ČR(CZ) GBP108/12/G108
Institutional support: RVO:67985823 ; RVO:61389005
Keywords : brest naoplasms * cell line * epithelial cells
OECD category: Biophysics; Biomaterials (as related to medical implants, devices, sensors) (FGU-C)
Impact factor: 0.773, year: 2019
Method of publishing: Limited access
https://doi.org/10.1093/rpd/ncz193

A comparison between breast cancer cell line MCF7 and human adipose-derived stem cells (ADSC) after irradiation by the same doses of megavoltage X-rays was performed. The cell growth, the induction of apoptosis and the expression of selected genes were analyzed. Irradiated MCF7 related to its control sample grows slower than ADSC and it undergoes apoptosis in much higher levels than ADSC. This was confirmed by real-time polymerase chain reaction as well, where the expression of apoptotic genes was found to be considerably higher for MCF7 than for ADSC. From the results of this project, it could be stated that MCF7 is more radiosensitive than ADSC.
Permanent Link: http://hdl.handle.net/11104/0308181