Nano-in-Micro Dual Delivery Platform for Chronic Wound Healing Applications

0523852 - FGÚ 2021 RIV CH eng J - Journal Article
Zárubová, Jana - Hasani-Sadrabadi, M. M. - Bačáková, Lucie - Li, S.
Nano-in-Micro Dual Delivery Platform for Chronic Wound Healing Applications.
Micromachines. Roč. 11, č. 2 (2020), č. článku 158. E-ISSN 2072-666X
R&D Projects: GA MŠMT(CZ) LQ1604
Grant - others:AV ČR(CZ) MSM200111802
Program: Program na podporu mezinárodní spolupráce začínajících výzkumných pracovníků
Institutional support: RVO:67985823
Keywords : chronic wounds * angiogenesis * antibacterial properties * drug delivery * microfluidics * nanoparticles * microparticles
OECD category: Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)
Impact factor: 2.891, year: 2020
Method of publishing: Open access
https://doi.org/10.3390/mi11020158

Here, we developed a combinatorial delivery platform for chronic wound healing applications. A microfluidic system was utilized to form a series of biopolymer-based microparticles with enhanced affinity to encapsulate and deliver vascular endothelial growth factor (VEGF). Presence of heparin into the structure can significantly increase the encapsulation efficiency up to 95% and lower the release rate of encapsulated VEGF. Our in vitro results demonstrated that sustained release of VEGF from microparticles can promote capillary network formation and sprouting of endothelial cells in 2D and 3D microenvironments. These engineered microparticles can also encapsulate antibiotic-loaded nanoparticles to offer a dual delivery system able to fight bacterial infection while promoting angiogenesis. We believe this highly tunable drug delivery platform can be used alone or in combination with other wound care products to improve the wound healing process and promote tissue regeneration.
Permanent Link: http://hdl.handle.net/11104/0308128