Highly effective anti-tumor nanomedicines based on HPMA copolymer conjugates with pirarubicin prepared by controlled RAFT polymerization

0523539 - ÚMCH 2021 RIV GB eng J - Journal Article
Randárová, Eva - Nakamura, H. - Islam, R. - Studenovský, Martin - Mamoru, H. - Fang, J. - Chytil, Petr - Etrych, Tomáš
Highly effective anti-tumor nanomedicines based on HPMA copolymer conjugates with pirarubicin prepared by controlled RAFT polymerization.
Acta Biomaterialia. Roč. 106, 1 April (2020), s. 256-266. ISSN 1742-7061. E-ISSN 1878-7568
R&D Projects: GA ČR(CZ) GA17-13283S; GA ČR(CZ) GA19-01417S; GA ČR(CZ) GJ19-00956Y; GA MŠMT(CZ) LTAUSA18083; GA MŠMT(CZ) LO1507
Institutional support: RVO:61389013
Keywords : HPMA polymer conjugate * pirarubicin * RAFT polymerization
OECD category: Polymer science
Impact factor: 8.947, year: 2020
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S1742706120300908?via%3Dihub

Here, we describe innovative synthesis of well-defined biocompatible N-(2-hydroxypropyl) methacrylamide (HPMA)-based polymer carriers and their drug conjugates with pirarubicin intended for controlled drug delivery and pH-triggered drug activation in tumor tissue. Polymer carrier synthesis was optimized to obtain well-defined linear HPMA-based polymer precursor with dispersity close to 1 and molar mass close to renal threshold with minimal synthesis steps. The developed synthesis enables preparation of tailored polymer nanomedicines with highly enhanced biological behavior in vivo, especially the biodistribution, urine elimination, tumor accumulation and anticancer activity.
Permanent Link: http://hdl.handle.net/11104/0308243