Introduction to RNAi and miRNA pathways

0523488 - ÚMG 2020 RIV CZ eng M - Monography Chapter
Svoboda, Petr
RNAi and miRNA pathways in fish.
Introduction to RNAi and miRNA pathways. Praha: Karolinum, 2019 - (Svoboda, P.), s. 1-339. ISBN 978-80-246-4372-4
R&D Projects: GA MŠMT LO1220
Institutional support: RVO:68378050
Keywords : dsRNA * siRNA * miRNA * Dicer * TARBP2 * PACT * Argonaute
OECD category: Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

RNA silencing denotes sequence-specific repression mediated by small RNAs. In vertebrates, there are two closely related pathways, which share several protein factors: RNA interference (RNAi) and microRNA (miRNA) pathway. The miRNA pathway serves to regulate endogenous protein-coding gene expression and has been implicated in many biological processes. RNAi generally serves as a form of innate immunity targeting viruses and mobile elements. This work reviews miRNA and RNAi pathways in fish. RNAi and other dsRNA-responding pathways in fish are very much like those in mammals, which is remarkable considering the mammalian and fish lineages separated in Paleozoicum some 400 million years ago. The miRNA pathway is likely the dominant small RNA pathway while, similarly to other vertebrates, the existence and functionality of endogenous RNAi remains unclear.
Permanent Link: http://hdl.handle.net/11104/0307850