Number of the records: 1
Advances in Disease Models
- 1.0523216 - ÚMG 2020 RIV CZ eng M - Monography Chapter
Kreplová, Michaela
Generation of three-dimensional retinal organoids from mouse embryonic stem cells.
Advances in Disease Models. Praha: OPTIO CZ, 2019 - (Bartůněk, P.), s. 57-63. ISBN 978-80-88011-06-4
R&D Projects: GA MŠMT LO1419
Institutional support: RVO:68378050
Keywords : retinal organoids * eye development * eye diseases
OECD category: Cell biology
It is well established that three-dimensional retinal organoids can be generated from mouse embryonic stem cells (mESCs). Growth and specification of these organoids is temporally and spatially comparable with eye development in vivo. A protocol for successful generation of mouse retinal organoids using EB3/5 mESCs was implemented and optimized. Retinal organoids can be utilized in drug testing, for high-throughput screening techniques, disease modeling or for producing cells suitable for transplantation to cure eye diseases.
Permanent Link: http://hdl.handle.net/11104/0307593
Number of the records: 1