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G-Quadruplex Nucleic Acids
- 1.0523166 - BFÚ 2020 RIV US eng M - Monography Chapter
Kejnovská, Iva - Renčiuk, Daniel - Palacký, Jan - Vorlíčková, Michaela
CD study of the G-Quadruplex conformation.
G-Quadruplex Nucleic Acids. New York: Humana, 2019, s. 25-44. ISBN 978-1-4939-9666-7
R&D Projects: GA ČR GA17-12075S; GA MŠMT EF15_003/0000477
Institutional support: RVO:68081707
Keywords : Guanine quadruplex * Circular dichroism spectroscopy * Interpretation of CD spectra
OECD category: Biophysics
https://www.springer.com/gp/book/9781493996650
Circular Dichroic (CD) spectroscopy is one of the most frequently used methods for quadruplex studies and in general for studies of conformational properties of nucleic acids. The reason is its high sensitivity to even slight changes in mutual orientation of absorbing bases of DNA. CD can reveal formation of particular structural DNA arrangements, can be used to search for the conditions stabilizing the structures, to follow the transitions between various structural states, to explore kinetics of their appearance, to determine thermodynamic parameters and also to detect formation of higher order structures.
Permanent Link: http://hdl.handle.net/11104/0307587
Number of the records: 1