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Green tea can supress rabbit ovarian functions in vitro and in vivo

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    0522735 - ÚMG 2020 RIV US eng J - Journal Article
    Balazi, A. - Sirotkin, A. V. - Foldesiova, M. - Makovický, Peter - Chrastinova, L. - Makovický, P. - Chrenek, P.
    Green tea can supress rabbit ovarian functions in vitro and in vivo.
    Theriogenelogy. Roč. 127, March (2019), s. 72-79. ISSN 0093-691X. E-ISSN 1879-3231
    Institutional support: RVO:68378050
    Keywords : Rabbit female * Green tea * Steroid hormones * Conception rate * Ovaries histology * Fecundity
    OECD category: Reproductive biology (medical aspects to be 3)
    Impact factor: 2.094, year: 2019
    Method of publishing: Open access
    https://www.sciencedirect.com/science/article/abs/pii/S0093691X18306472?via%3Dihub

    The aim of present study was to evaluate the action of green tea and its constituents on rabbit ovarian functions and some non-reproductive indexes. In in vitro experiments, rabbit ovarian fragments were cultured with green tea constituents epigallocatechin-3-gallate (EGCG), green tea polyphenols (GTPP) and resveratrol (RSV) (at 0, 1, 10 or 100 mu g/mL medium). The accumulation of an apoptosis marker caspase 3 and the release of progesterone (P4) and testosterone (T) were measured. In in vivo experiments, does were fed a standard diet or a diet enriched with green tea powder. The weight gain, mortality, ovarian length and weight, conception and kindling rate, number of liveborn, stillborn, and weaned pups, diameter of ovarian follicles and some blood haematological and biochemical parameters were analysed. Culture of ovarian fragments with EGCG increased accumulation of caspase 3, whilst both CUP and RSV decreased it. EGCG inhibited both P4 and T output, GTPP stimulated P4 and inhibited T, whilst RSV promoted release of both P4 and T. Feeding with green tea increased ovarian length and diameter of ovarian non-ovulated peri-ovulatory haemorrhagic but not of primary and secondary growing follicles. Furthermore, green tea reduced conception and kindling rate, the number of liveborn and weaned pups, increased female mortality but not their weight gain. It reduced platelet distribution width, but it did not affect other haematological and biochemical indexes.
    Permanent Link: http://hdl.handle.net/11104/0307180

     
     
Number of the records: 1  

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