Evaluation of Second-Generation Lipophosphonoxins as Antimicrobial Additives in Bone Cement

0522685 - ÚOCHB 2021 RIV US eng J - Journal Article
Zborníková, Eva - Gallo, J. - Večeřová, R. - Bogdanová, K. - Kolář, M. - Vítovská, Dragana - Do Pham, Duy Dinh - Pačes, Ondřej - Mojr, Viktor - Šanderová, Hana - Ulrichová, J. - Galandáková, A. - Čadek, D. - Hrdlička, Z. - Krásný, Libor - Rejman, Dominik
Evaluation of Second-Generation Lipophosphonoxins as Antimicrobial Additives in Bone Cement.
ACS Omega. Roč. 5, č. 7 (2020), s. 3165-3171. ISSN 2470-1343. E-ISSN 2470-1343
R&D Projects: GA MZd(CZ) NV17-29680A
Institutional support: RVO:61388963 ; RVO:61388971
Keywords : bone cement * antibacterial * lipophosphonoxin
OECD category: Biomaterials (as related to medical implants, devices, sensors)
Impact factor: 3.512, year: 2020
Method of publishing: Open access
https://pubs.acs.org/doi/10.1021/acsomega.9b03072

Successful surgeries involving orthopedic implants depend on the avoidance of biofilm development on the implant surface during the early postoperative period. Here, we investigate the potential of novel antibacterial compounds—second-generation lipophosphonoxins (LPPOs II)—as additives to surgical bone cements. We demonstrate (i) excellent thermostability of LPPOs II, which is essential to withstand elevated temperatures during exothermic cement polymerization, (ii) unchanged tensile strength and elongation at the break properties of the composite cements containing LPPOs II compared to cements without additives, (iii) convenient elution kinetics on the order of days, and (iv) the strong antibiofilm activity of the LPPO II-loaded cements even against bacteria resistant to the medicinally utilized antibiotic, gentamicin. Thus, LPPOs II display promising potential as antimicrobial additives to surgical bone cements.
Permanent Link: http://hdl.handle.net/11104/0307134