Non-thermal plasma, as a physicochemical cue to induce redox imbalance in living cells

0522422 - FZÚ 2020 US eng A - Abstract
Smolková, Barbora - Lunova, Mariia - Lynnyková, Anna - Uzhytchak, Mariia - Churpita, Olexandr - Jirsa, M. - Kubinová, Šárka - Lunov, Oleg - Dejneka, Alexandr
Non-thermal plasma, as a physicochemical cue to induce redox imbalance in living cells.
FEBS Open Bio. Vol. 9. New Jersey: Wiley, 2019 - (De la Rosa, M.). s. 175-175. ISSN 2211-5463. E-ISSN 2211-5463.
[FEBS Congress, from Molecules to Living Systems /44./. 06.07.2019-11.07.2019, Krakov]
Institutional support: RVO:68378271
Keywords : ROS * NTP * plasma
OECD category: Biophysics

Reactive oxygen species (ROS) are involved in essential cellular processes and act as signalling molecules in various organisms. Depending on their concentration, ROS may promote cell proliferation and differentiation, or induce oxidative damage and cell death. Recent evidences suggest, that non-thermal plasma (NTP), an ionised gas, containing chemically active species. A number of studies have shown the effects of NTP in many biomedical applications. However, the exact molecular mechanisms of NTP on cells and human remain obscure. In our study, we examined the effects of NTP on two bacterial strains. Additionally, to assess the effect of NTP on more complex system we use three human hepatic cancer cell lines. Our results demonstrate that excessive ROS accumulation results in dysfunction of mitochondria and cell death. In summary, our findings provide non-thermal plasma as interesting therapeutic approach to regulate redoxbased processes in the living cell.

Permanent Link: http://hdl.handle.net/11104/0306919