Salicylic Acid Targets Protein Phosphatase 2A to Attenuate Growth in Plants

0522413 - ÚEB 2020 RIV GB eng J - Journal Article
Tan, S. - Abas, M. - Verstraeten, I. - Glanc, M. - Molnár, G. - Hajný, Jakub - Lasák, Pavel - Petřík, Ivan - Russinova, E. - Petrášek, Jan - Novák, Ondřej - Pospíšil, Jiří - Friml, J.
Salicylic Acid Targets Protein Phosphatase 2A to Attenuate Growth in Plants.
Current Biology. Roč. 30, č. 3 (2020), s. 381-395. ISSN 0960-9822. E-ISSN 1879-0445
R&D Projects: GA MŠMT(CZ) EF16_019/0000738
Grant - others:OPPK(XE) CZ.2.16/3.1.00/21519
Institutional support: RVO:61389030
Keywords : NPR1 * PIN * PP2A
OECD category: Biochemical research methods
Impact factor: 10.834, year: 2020
Method of publishing: Open access
https://doi.org/10.1016/j.cub.2019.11.058

Plants, like other multicellular organisms, survive through a delicate balance between growth and defense against pathogens. Salicylic acid (SA) is a major defense signal in plants, and the perception mechanism as well as downstream signaling activating the immune response are known. Here, we identify a parallel SA signaling that mediates growth attenuation. SA directly binds to A subunits of protein phosphatase 2A (PP2A), inhibiting activity of this complex. Among PP2A targets, the PIN2 auxin transporter is hyperphosphorylated in response to SA, leading to changed activity of this important growth regulator. Accordingly, auxin transport and auxin-mediated root development, including growth, gravitropic response, and lateral root organogenesis, are inhibited. This study reveals how SA, besides activating immunity, concomitantly attenuates growth through crosstalk with the auxin distribution network. Further analysis of this dual role of SA and characterization of additional SA-regulated PP2A targets will provide further insights into mechanisms maintaining a balance between growth and defense.
Permanent Link: http://hdl.handle.net/11104/0306911