Amphiphilic Dendritic Compounds for Drug Delivery Purposes.

0521919 - ÚCHP 2020 LT eng A - Abstract
Edr, Antonín - Strašák, Tomáš
Amphiphilic Dendritic Compounds for Drug Delivery Purposes.
Book of Abstracts. -: -, 2019. s. 85. ISBN N.
[Nano2Clinic – Cancer Nanomedicine – from the bench to the bedside. 15.10.2019-17.10.2019, Riga]
Institutional support: RVO:67985858
Keywords : dendron * drug delivery system * amphiphilic
OECD category: Organic chemistry

Recently, a high biomedical potential of phosphonium dendrimers was discovered in our group. Following that, the work aims on preparation of amphiphilic of dendritic substances such as 1 (Figure 1) which could serve as drug delivery systems in forms of supramolecular objects (e.g. liposomes). Primarily, molecules bearing phosphonium groups as a polar domain are prepared, however, designed synthesis is also used for preparation of non-ionic amphiphiles bearing hydroxyl groups. A main goal is to be able to assemble supramolecular structures which could transport defined siRNA (short interfering RNA) to cytoplasm but other applications are
possible as well.
Permanent Link: http://hdl.handle.net/11104/0306465