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Do stereoisomers of homocysteic acid exhibit different convulsant action in immature rats?

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    0521782 - FGÚ 2020 RIV CZ eng J - Journal Article
    Mareš, Pavel - Folbergrová, Jaroslava - Haugvicová, Renata - Kubová, Hana
    Do stereoisomers of homocysteic acid exhibit different convulsant action in immature rats?
    Physiological Research. Roč. 68, Suppl.3 (2019), S361-S366. ISSN 0862-8408. E-ISSN 1802-9973
    R&D Projects: GA ČR(CZ) GA18-09296S
    Institutional support: RVO:67985823
    Keywords : homocysteic acid * seizures * immature rats * NMDA antagonists * AMPA antagonists
    OECD category: Neurosciences (including psychophysiology
    Impact factor: 1.655, year: 2019
    Method of publishing: Open access
    http://www.biomed.cas.cz/physiolres/pdf/2019/68_S361.pdf

    Mechanism of ictogenesis of D- and L-stereroisomers of
    homocysteic acid was studied in 12-day-old rats by means of
    antagonists of N-methyl-D-aspartate (NMDA) and alpha-amino-3-
    hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors.
    There was no qualitative difference between the two
    stereoisomers in generation of emprosthotonic (flexion) as well
    as generalized tonic-clonic seizures. Moderate differences were
    observed in the first, nonconvulsive effects of the two isomers.
    As generation of the two types of seizures is concerned, NMDA
    and AMPA participate in generalized tonic-clonic seizures whereas
    NMDA receptors play a dominant role in generation of flexion
    seizures.

    Permanent Link: http://hdl.handle.net/11104/0306354

     
     
Number of the records: 1  

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