Do stereoisomers of homocysteic acid exhibit different convulsant action in immature rats?

0521782 - FGÚ 2020 RIV CZ eng J - Journal Article
Mareš, Pavel - Folbergrová, Jaroslava - Haugvicová, Renata - Kubová, Hana
Do stereoisomers of homocysteic acid exhibit different convulsant action in immature rats?
Physiological Research. Roč. 68, Suppl.3 (2019), S361-S366. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA ČR(CZ) GA18-09296S
Institutional support: RVO:67985823
Keywords : homocysteic acid * seizures * immature rats * NMDA antagonists * AMPA antagonists
OECD category: Neurosciences (including psychophysiology
Impact factor: 1.655, year: 2019
Method of publishing: Open access
http://www.biomed.cas.cz/physiolres/pdf/2019/68_S361.pdf

Mechanism of ictogenesis of D- and L-stereroisomers of
homocysteic acid was studied in 12-day-old rats by means of
antagonists of N-methyl-D-aspartate (NMDA) and alpha-amino-3-
hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors.
There was no qualitative difference between the two
stereoisomers in generation of emprosthotonic (flexion) as well
as generalized tonic-clonic seizures. Moderate differences were
observed in the first, nonconvulsive effects of the two isomers.
As generation of the two types of seizures is concerned, NMDA
and AMPA participate in generalized tonic-clonic seizures whereas
NMDA receptors play a dominant role in generation of flexion
seizures.

Permanent Link: http://hdl.handle.net/11104/0306354