Liquid crystalline nanostructures as PEGylated reservoirs of omega-3 polyunsaturated fatty acids: structural insights toward delivery formulations against neurodegenerative disorders

0521653 - FZÚ 2020 RIV US eng J - Journal Article
Angelova, A. - Drechsler, M. - Garamus, V. M. - Angelov, Borislav
Liquid crystalline nanostructures as PEGylated reservoirs of omega-3 polyunsaturated fatty acids: structural insights toward delivery formulations against neurodegenerative disorders.
ACS Omega. Roč. 3, č. 3 (2018), s. 3235-3247. ISSN 2470-1343. E-ISSN 2470-1343
R&D Projects: GA MŠMT EF15_003/0000447
Grant - others:OP VVV - ELIBIO(XE) CZ.02.1.01/0.0/0.0/15_003/0000447
Institutional support: RVO:68378271
Keywords : docosahexaenoic acid * phase-behavior * lipid nanoparticles * internal structure * macromolecular drugs * physical-properties * multidrug delivery * neuronal survival * membrane domain * cubic phase
OECD category: Fluids and plasma physics (including surface physics)
Impact factor: 2.584, year: 2018
Method of publishing: Open access

Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) are bioactive lipids with considerable impact in medicine and nutrition. These compounds exert structuring effects on the cellular membrane organization, regulate the gene expression, and modulate various signaling cascades and metabolic processes. The purpose of the present work is to demonstrate the structural features of omega-3 PUFA-containing three-dimensional supramolecular lipid assemblies suitable for pharmaceutical applications that require soft porous carriers. We investigate the liquid crystalline structures formed upon mixing of eicosapentaenoic acid (EPA, 20:5) with the lyotropic nonlamellar lipid monoolein and the formation of multicompartment assemblies.
Permanent Link: http://hdl.handle.net/11104/0306242