Nuclear Phosphoinositides-Versatile Regulators of Genome Functions

0521616 - ÚMG 2020 RIV CH eng J - Journal Article
Castano, Enrique - Yildirim, Sukriye - Fáberová, Veronika - Krausová, Alžběta - Uličná, Lívia - Paprčková, Darina - Sztacho, Martin - Hozák, Pavel
Nuclear Phosphoinositides-Versatile Regulators of Genome Functions.
Cells. Roč. 8, č. 7 (2019). E-ISSN 2073-4409
R&D Projects: GA ČR(CZ) GA17-09103S; GA ČR GA19-05608S; GA TA ČR(CZ) TE01020118; GA MŠMT(CZ) ED1.1.00/02.0109; GA MŠMT(CZ) LM2015062
Institutional support: RVO:68378050
Keywords : phosphoinositides * cell nucleus * genome * gene expression
OECD category: Cell biology
Impact factor: 4.366, year: 2019
Method of publishing: Open access
https://www.mdpi.com/2073-4409/8/7/649

The many functions of phosphoinositides in cytosolic signaling were extensively studied, however, their activities in the cell nucleus are much less clear. In this review, we summarize data about their nuclear localization and metabolism, and review the available literature on their involvements in chromatin remodeling, gene transcription, and RNA processing. We discuss the molecular mechanisms via which nuclear phosphoinositides, in particular phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2), modulate nuclear processes. We focus on PI(4,5)P2's role in the modulation of RNA polymerase I activity, and functions of the nuclear lipid islets recently described nucleoplasmic PI(4,5)P2-rich compartment involved in RNA polymerase II transcription. In conclusion, the high impact of the phosphoinositide protein complexes on nuclear organization and genome functions is only now emerging and deserves further thorough studies.
Permanent Link: http://hdl.handle.net/11104/0306215