Laser irradiation induces mitochondrial dysfunction in hepatic cells

0521405 - FZÚ 2020 RIV US eng C - Conference Paper (international conference)
Lynnyková, Anna - Smolková, Barbora - Uzhytchak, Mariia - Egorova, D. - Kulikov, A. - Lunova, Mariia - Kubinová, Šárka - Dejneka, Alexandr - Lunov, Oleg
Laser irradiation induces mitochondrial dysfunction in hepatic cells.
Medical Laser Applications and Laser-Tissue Interactions IX. Bellingham: SPIE, 2019 - (Lilge, L.; Philipp, C.), s. 1-4, č. článku 1107911. Proceedings of SPIE, 11079. ISBN 978-151062851-9. ISSN 0277-786X.
[Medical Laser Applications and Laser-Tissue Interactions IX 2019. Munich (DE), 23.06.2019-24.06.2019]
Institutional support: RVO:68378271 ; RVO:68378041
Keywords : laser irradiation * hepatic cells * cell death * mitochondrial dysfunction
OECD category: Biophysics; Biophysics (UEM-P)

Laser irradiation has been recognized as a promising tool across a number of biomedical applications. However, understanding the molecular mechanisms and cellular responses remains incomplete. Here, we investigated the mechanism involved in the apoptotic process in human hepatic cells under laser irradiation. Our data show that the laser-mediated alternation of mitochondrial membrane potential leads apoptosis in Huh7 and Alexander cells. Contrary, HepG2 cells are resistant to laser induced cell death. The observed link between mitochondrial membrane potential and cytotoxicity could be a fundamental phenomenon in laser-induced cell apoptosis.

Permanent Link: http://hdl.handle.net/11104/0306036