Beauverolide F >98%

0521034 - BC 2020 RIV CZ eng L - Prototype, f. module
Heneberg, P. - Jegorov, Alexandr - Kružberská, Pavla - Šimek, Petr - Vodrážka, Petr
Beauverolide F >98%.
Internal code: BVD-F ; 2018
Technical parameters: Kontakt na řešitele projektu Dr. P. Heneberg, 3LF UK T: +420 267 102 914 M: +420 775 311 177 e-mail: petr.heneberg@lf3.cuni.cz Kontakt na osoby odpovědné za komerční využití: Kontaktní osoba za autory funkčního vzorku Ing. Petr Maršík Vedoucí Úseku transferu technologií Biologické centrum AV ČR, v. v. i. THS – Úsek transferu technologií Branišovská 1160/31 370 05 České Budějovice T: +420 387 775 060 M: +420 777 468 681 www.bc.cas.cz Kontaktní osoba za odběratele Mr. Michael Schaeffler Cfm Oskar Tropitzsch GmbH Waldershofer Str. 49-51 95615 Marktredwitz, Germany Phone: +49-(0)9231-9619-30 Fax: +49-(0)9231-9619-60 Email: michael.schaeffler@cfmot.de Homepage: http://www.cfmot.de
Economic parameters: Látka je aktivně nabízena v katalogu firmy Oskar Tropitzsch GmbH, která průběžně oslovuje vybrané subjekty ze svého portfolia odběratelů. Webová stránka odběratele: http://www.cfmot.de/en/ Prodejní cena za 1 mg čisté látky je nastavena na 250,- EUR.
Grant - others:MZ(CZ) NV15-32432A
Institutional support: RVO:60077344
Keywords : Beauveria bassiana * cyclodepsipeptide * macrophage * metabolism * beauverolide
OECD category: Medicinal chemistry

Beauveriolide F, of >98 % purity (HPLC), CAS 75947-00-1, the cyclopeptide (3R,6S,9S)-6,9-dibenzyl-3-[(2R)-butan-2-yl]-13-hexan-2-yl-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone, where: 3OH4MeC8a stands for the 3(R)-hydroxy-4(S)-methyloctanoic acid Residue, Phe, L (S)-phenylalanine, Leu, D (R)-leucine. The substance was isolated by a newly developed procedure from the production strain of the fungus Beauveria (monosporic isolate). It is produced at a purity > 98%. The physicochemical properties of the product have been described in detail in the accompanying safety data sheet (SDD) and the functional sample certificate. The substance is one of major bioactive metabolites of several species of entomopathogenic fungi of the genus Beauveria, Isaria or Paecilomyces. BVD-F is predicted to inhibit the enzyme acyl CoA: cholesterol acyltransferase (ACAT1 and ACAT2) and is predicted to be included in a new class of substances that reduce the accumulation of β-amyloid peptides in the brain, one of the major manifestations of Alzheimer's disease and to slow down some neurodegenerative processes during aging.
Permanent Link: http://hdl.handle.net/11104/0305686