Synthesis and characterization of Au nanoshells with a magnetic core and betaine derivatives

0520754 - FZÚ 2020 RIV NL eng J - Journal Article
Bertok, T. - Lorencova, L. - Hroncekova, S. - Gajdosova, V. - Jane, E. - Hires, M. - Kasák, P. - Kaman, Ondřej - Sokol, R. - Bella, V. - Eckstein, A.A. - Mošnáček, J. - Vikartovská, A. - Tkac, J.
Synthesis and characterization of Au nanoshells with a magnetic core and betaine derivatives.
MethodsX. Roč. 6, č. 1 (2019), s. 1999-2012. E-ISSN 2215-0161
R&D Projects: GA ČR GA16-04340S
Institutional support: RVO:68378271
Keywords : Au nanoshells with a magnetic core * X-ray diffraction * transmission electron microscopy * Fourier transform infrared spectroscopy * nuclear magnetic resonance
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Method of publishing: Open access

The article describes preparation, characterization and further modification of hybrid magnetic particles (Au nanoshells with a magnetic core (MPs@silica@Au)) by zwitterionic molecules bearing diazonium functional groups. Such hybrid magnetic particles modified by zwitterionic molecules exhibit the following features: Responsiveness towards external magnetic field applicable for various enrichment strategies due to magnetic core,Golden outer layer exhibiting free surface plasmons could be used for grafting of zwitterionic molecules via diazonium functionality,Zwitterionic interface on such particles provides resistivity towards non-specific protein binding, and at the same time such interface was applied for immobilization of antibodies against prostate specific antigen (PSA) applied for selective enrichment of PSA from serum samples with subsequent electrochemical assays.

Permanent Link: http://hdl.handle.net/11104/0305424