Mosquito adaptations to hematophagia impact pathogen transmission

0520375 - BC 2020 RIV NL eng J - Journal Article
Nouzová, Marcela - Clifton, M. E. - Noriega, F. G.
Mosquito adaptations to hematophagia impact pathogen transmission.
Current Opinion in Insect Science. Roč. 34, AUG 2019 (2019), s. 21-26. ISSN 2214-5745. E-ISSN 2214-5753
Institutional support: RVO:60077344
Keywords : midgut serine proteases * aedes-aegypti * anopheles-gambiae * plasmodium infection * peritrophic matrix * parasite chitinase * dengue-virus * protein * behavior * vector
OECD category: Tropical medicine
Impact factor: 4.565, year: 2019
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S221457451830141X

Mosquito-borne diseases such as Dengue fever, Chikungunya, and Malaria are critical threats to public health in many parts of the world. Female mosquitoes have evolved multiple adaptive mechanisms to hematophagy, including the ability to efficiently draw and digest blood, as well as the ability to eliminate excess fluids and toxic by-products of blood digestion. Pathogenic agents enter the mosquito digestive tract with the blood meal and need to travel through the midgut and into the hemocele in order to reach the salivary glands and infect a new host. Pathogens need to adjust to these hostile gut, hemocele, and salivary gland environments, and when possible influence the physiology and behavior of their hosts to enhance transmission.
Permanent Link: http://hdl.handle.net/11104/0305056