(1S,2S)-cyclohexane-1,2-diamine-based organosilane fibres as a powerful tool against pathogenic bacteria

0519618 - ÚMCH 2021 RIV CH eng J - Journal Article
Máková, V. - Holubová, B. - Tetour, D. - Brus, Jiří - Řezanka, M. - Rysová, M. - Hodačová, J.
(1S,2S)-cyclohexane-1,2-diamine-based organosilane fibres as a powerful tool against pathogenic bacteria.
Polymers. Roč. 12, č. 1 (2020), s. 1-12, č. článku 206. E-ISSN 2073-4360
Institutional support: RVO:61389013
Keywords : organic-inorganic hybrids * organo-bridged silsesquioxane * sol-gel process
OECD category: Polymer science
Impact factor: 4.329, year: 2020
Method of publishing: Open access
https://www.mdpi.com/2073-4360/12/1/206

An urgent need to find an effective solution to bacterial resistance is pushing worldwide research for highly effective means against this threat. Newly prepared hybrid organosilane fibres consisting of a (1S,2S)-cyclohexane-1,2-diamine derivative, interconnected in the fibre network via covalent bonds, were fully characterised via different techniques, including FTIR, TGA-FTIR, SEM-EDS, and solid-state NMR. Fibrous samples were successfully tested against two types of pathogenic bacterial strains, namely Staphylococcus aureus, and Pseudomonas aeruginosa. The obtained results, showing >99.9% inhibition against Staphylococcus aureus and Pseudomonas aeruginosa in direct contact compared to the control, may help particularly in case of infections, where there is an urgent need to treat the infection in direct contact. From this point of view, the above-mentioned fibrous material may find application in wound healing. Moreover, this new material has a positive impact on fibroblasts viability.
Permanent Link: http://hdl.handle.net/11104/0306210