Lipidated peptides as neuroprotective agents

0519553 - ÚOCHB 2020 RIV eng P - Patent Document
Maletínská, Lenka - Železná, Blanka - Blechová, Miroslava - Špolcová, Andrea - Mikulášková, Barbora - Kuneš, Jaroslav
Lipidated peptides as neuroprotective agents.
2019. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 19.06.2019. Patent Number: EP3149029
R&D Projects: GA TA ČR(CZ) TE01020028
Institutional support: RVO:61388963
Keywords : prolactin-releasing peptide * lipidated * neuroprotection
OECD category: Pharmacology and pharmacy
https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20190619&DB=&locale=en_EP&CC=EP&NR=3149029B1&KC=B1&ND=4#

The invention provides lipidated neuropeptides based on PrRP31, PrRP20, containing C14 and/or C16 fatty acid, wherein a sequence of IRPVGRF-NH2 at the C-terminus is variable in the site of isoleucine, valine and phenylalanine, said fatty acid is bound in position 1 or 11 for PrRP31 or its analog and in position 1 or 7 for PrRP20 or its analog, the fatty acid is bound directly or through a hydrophilic linker X2, for use in the treatment and prevention of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), cognitive impairment no dementia (CIND), brain trauma, and neurodegenerative changes and disorders.
Permanent Link: http://hdl.handle.net/11104/0304651