Capillary Electrophoresis with Capacitively Coupled Contactless Conductivity Detection for Quantitative Analysis of Dried Blood Spots with Unknown Blood Volume

0519519 - ÚIACH 2021 RIV US eng J - Journal Article
Dvořák, Miloš - Ryšavá, Lenka - Kubáň, Pavel
Capillary Electrophoresis with Capacitively Coupled Contactless Conductivity Detection for Quantitative Analysis of Dried Blood Spots with Unknown Blood Volume.
Analytical Chemistry. Roč. 92, č. 1 (2020), s. 1557-1564. ISSN 0003-2700. E-ISSN 1520-6882
R&D Projects: GA ČR(CZ) GA18-13135S
Institutional support: RVO:68081715
Keywords : capillary electrophoresis * contactless conductivity detection * dried blood spots
OECD category: Analytical chemistry
Impact factor: 6.986, year: 2020
Method of publishing: Limited access

An all-in-one approach for the simultaneous determination of exact blood volume in the DBS punch and the quantitation of target analytes is presented. The capillary blood volume in a DBS eluate is calculated from the concentrations of the inorganic blood constituents (K+, Na+, or Cl−) and is used for exact quantification of target analytes (amino acids), which are all determined in a single analysis by capillary electrophoresis with contactless conductivity detection.
Permanent Link: http://hdl.handle.net/11104/0304487