Ferrocenes as new anticancer drug candidates: Determination of the mechanism of action

0519357 - ÚFCH JH 2021 RIV NL eng J - Journal Article
Skoupilová, H. - Bartošík, M. - Sommerová, L. - Pinkas, Jiří - Vaculovič, T. - Kanický, V. - Karban, Jindřich - Hrstka, R.
Ferrocenes as new anticancer drug candidates: Determination of the mechanism of action.
European Journal of Pharmacology. Roč. 867, JAN 2020 (2020), č. článku 172825. ISSN 0014-2999. E-ISSN 1879-0712
R&D Projects: GA ČR(CZ) GA17-05838S
Institutional support: RVO:61388955 ; RVO:67985858
Keywords : transferrin * iron * ferroquine * cisplatin * Ferrocene * Ovarian cancer * Cellular uptake * Transferrin * Transferrin receptor * Reactive oxygen species
OECD category: Physical chemistry; Organic chemistry (UCHP-M)
Impact factor: 4.432, year: 2020
Method of publishing: Limited access

Chemotherapy plays an essential role in the management of cancer worldwide. However, it is a non-specific treatment limited by major drawbacks, thus identification and testing of new promising molecular structures representing potential drug candidates are urgently needed. In this work, ferrocene complexes as potential antitumor drugs that display cytotoxicity in low micromolar concentrations against ovarian cancer cells A2780 and SK-OV-3 were investigated to identify their mode of action. Their mechanism of cellular accumulation was studied using differential pulse voltammetry and inductively coupled plasma mass spectrometry. Their mode of cell death induction was determined by changes in the mitochondrial membrane potential, production of reactive oxygen species and by Annexin V staining.
Permanent Link: http://hdl.handle.net/11104/0304348