New series of water-soluble thiosemicarbazones and their copper(II) complexes as potentially promising anticancer compounds

0519181 - FZÚ 2020 RIV NL eng J - Journal Article
Mirzaahmadi, A. - Hosseini-Yazdi, S.A. - Safarzadeh, E. - Baradaran, B. - Samoľová, Erika - Dušek, Michal
New series of water-soluble thiosemicarbazones and their copper(II) complexes as potentially promising anticancer compounds.
Journal of Molecular Liquids. Roč. 293, Nov (2019), s. 1-11, č. článku 111412. ISSN 0167-7322. E-ISSN 1873-3166
R&D Projects: GA MŠMT(CZ) LO1603; GA ČR(CZ) GA18-10504S
EU Projects: European Commission(CZ) CZ.2.16/3.1.00/24510
Institutional support: RVO:68378271
Keywords : anticancer activity * apoptosis * cell cycle * cytotoxicity * Schiff base * water-soluble thiosemicarbazone
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 5.065, year: 2019
Method of publishing: Limited access
https://doi.org/10.1016/j.molliq.2019.111412

New water soluble thiosemicarbazone ligands, namely 3-(3-{[(aminocarbonothioyl) hydrazono]methyl}-4-hydroxybenzyl)-1-methyl-1H-imidazol-3-ium chloride (H2L1Cl), 3-[4-hydroxy-3-({[(methylamino)carbonothioyl]hydrazono}methyl)benzyl]-1-methyl-1H-imidazol-3-ium chloride (H2L2Cl) and 3-(3-{[(anilinocarbonothioyl)hydrazono]methyl}-4-hydroxybenzyl)-1-methyl-1H-imidazol-3-ium chloride (H2L3Cl) were synthesized through 1:1 condensation reaction of thiosemicarbazide derivatives with 3-(3-formyl-4- hydroxybenzyl)-1-methyl-1H-imidazole-3-ium chloride (SalimiCl) and characterized by elemental analysis and spectroscopic methods (UV–Vis, 1H NMR, FTIR).
Permanent Link: http://hdl.handle.net/11104/0304209