Cytomegalovirus distribution and evolution in hominines

0519103 - ÚBO 2020 RIV GB eng J - Journal Article
Murthy, S. - O'Brien, K. - Agbor, A. - Angedakin, S. - Arandjelovic, M. - Ayimisin, E. A. - Bailey, E. - Bergl, R. A. - Brazzola, G. - Dieguez, P. - Eno-Nku, M. - Eshuis, H. - Fruth, B. - Gillespie, T. R. - Ginath, Y. - Gray, M. - Herbinger, I. - Jones, S. - Kehoe, L. - Kühl, H. - Kujirakwinja, D. - Lee, K. - Madinda, N. F. - Mitamba, G. - Muhindo, E. - Nishuli, R. - Ormsby, L. J. - Petrželková, Klára Judita - Plumptre, A. J. - Robbins, M. M. - Sommer, V. - Ter Heegde, M. - Todd, A. - Tokunda, R. - Wessling, E. - Jarvis, M. A. - Leendertz, F. H. - Ehlers, B. - Calvignac-Spencer, S.
Cytomegalovirus distribution and evolution in hominines.
Virus Evolution. Roč. 5, č. 2 (2019), č. článku vez015. E-ISSN 2057-1577
Institutional support: RVO:68081766
Keywords : sequence alignment * b-virus * transmission * identification * replication * phylogenies * infection * selection * accuracy * origins * cytomegalovirus * hominine * host switch * codivergence * dsDNA virus
OECD category: Virology
Impact factor: 5.549, year: 2019
Method of publishing: Open access

Herpesviruses are thought to have evolved in very close association with their hosts. This is notably the case for cytomegaloviruses (CMVs, genus Cytomegalovirus) infecting primates, which exhibit a strong signal of co-divergence with their hosts. Some herpesviruses are however known to have crossed species barriers. Based on a limited sampling of CMV diversity in the hominine (African great ape and human) lineage, we hypothesized that chimpanzees and gorillas might have mutually exchanged CMVs in the past. Here, we performed a comprehensive molecular screening of all 9 African great ape species/ subspecies, using 675 fecal samples collected from wild animals. We identified CMVs in eight species/subspecies, notably generating the first CMV sequences from bonobos. We used this extended dataset to test competing hypotheses with various degrees of co-divergence/number of host switches while simultaneously estimating the dates of these events in a Bayesian framework. The model best supported by the data involved the transmission of a gorilla CMV to the panine (chimpanzee and bonobo) lineage and the transmission of a panine CMV to the gorilla lineage prior to the divergence of chimpanzees and bonobos, more than 800,000 years ago. Panine CMVs then co-diverged with their hosts. These results add to a growing body of evidence suggesting that viruses with a double-stranded DNA genome (including other herpesviruses, adenoviruses, and papillomaviruses) often jumped between hominine lineages over the last few million years.
Permanent Link: http://hdl.handle.net/11104/0304144