The Use of Tick Salivary Proteins as Novel Therapeutics

0518850 - BC 2020 RIV CH eng J - Journal Article
Chmelař, J. - Kotál, Jan - Kovaříková, A. - Kotsyfakis, Michalis
The Use of Tick Salivary Proteins as Novel Therapeutics.
Frontiers in Physiology. Roč. 10, JUN 26 2019 (2019), č. článku 812. ISSN 1664-042X. E-ISSN 1664-042X
R&D Projects: GA ČR(CZ) GA19-07247S; GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:60077344
Keywords : chemokine-binding protein * platelet-aggregation inhibitor * complement inhibitor * soft tick * gland transcriptome * fibrinogen receptor * serpins flex * disease * identification * cloning * ticks * therapeutics * immunomodulation * salivary proteins * anti-inflammatory proteins * hemostasis
OECD category: Biochemistry and molecular biology
Impact factor: 3.367, year: 2019
Method of publishing: Open access
https://www.frontiersin.org/articles/10.3389/fphys.2019.00812/full

The last three decades of research into tick salivary components have revealed several proteins with important pharmacological and immunological activities. Two primary interests have driven research into tick salivary secretions: the search for suitable pathogen transmission blocking or 'anti-tick' vaccine candidates and the search for novel therapeutics derived from tick salivary components. Intensive basic research in the field of tick salivary gland transcriptomics and proteomics has identified several major protein families that play important roles in tick feeding and overcoming vertebrate anti-tick responses. Moreover, these families contain members with unrealized therapeutic potential. Here we review the major tick salivary protein families exploitable in medical applications such as immunomodulation, inhibition of hemostasis and inflammation. Moreover, we discuss the potential, opportunities, and challenges in searching for novel tick-derived drugs.
Permanent Link: http://hdl.handle.net/11104/0304035