Message in a vesicle trans-kingdom intercommunication at the vector-host interface

0518848 - BC 2020 RIV GB eng J - Journal Article
Chávez, A.S.O. - O'Neal, A.J. - Santambrogio, L. - Kotsyfakis, Michalis - Pedra, J. H. F.
Message in a vesicle trans-kingdom intercommunication at the vector-host interface.
Journal of Cell Science. Roč. 132, č. 6 (2019), č. článku jcs224212. ISSN 0021-9533. E-ISSN 1477-9137
Institutional support: RVO:60077344
Keywords : extracellular vesicles * trypanosoma-cruzi * proteomic analysis * protein * exosomes * parasite * tick * leishmania * secretion * membrane * Extracellular vesicle * Arthropod-borne disease * Cell communication * Immunomodulation * Microbial transmission
OECD category: Cell biology
Impact factor: 4.573, year: 2019
Method of publishing: Open access
https://jcs.biologists.org/content/joces/132/6/jcs224212.full.pdf

Vector-borne diseases cause over 700,000 deaths annually and represent 17% of all infectious illnesses worldwide. This public health menace highlights the importance of understanding how arthropod vectors, microbes and their mammalian hosts interact. Currently, an emphasis of the scientific enterprise is at the vector-host interface where human pathogens are acquired and transmitted. At this spatial junction, arthropod effector molecules are secreted, enabling microbial pathogenesis and disease. Extracellular vesicles manipulate signaling networks by carrying proteins, lipids, carbohydrates and regulatory nucleic acids. Therefore, they are well positioned to aid in cell-to-cell communication and mediate molecular interactions. This Review briefly discusses exosome and microvesicle biogenesis, their cargo, and the role that nanovesicles play during pathogen spread, host colonization and disease pathogenesis. We then focus on the role of extracellular vesicles in dictating microbial pathogenesis and host immunity during transmission of vector-borne pathogens.
Permanent Link: http://hdl.handle.net/11104/0304040