Comparative genomics of Leishmania (Mundinia)

0518831 - BC 2020 RIV US eng J - Journal Article
Butenko, Anzhelika - Kostygov, A.Y. - Sádlová, J. - Kleschenko, Y. - Bečvář, T. - Podešvová, L. - Macedo, D. H. - Zihala, D. - Lukeš, Julius - Bates, P.A. - Volf, P. - Opperdoes, F. R. - Yurchenko, V.
Comparative genomics of Leishmania (Mundinia).
BMC Genomics. Roč. 20, č. 1 (2019), č. článku 726. ISSN 1471-2164. E-ISSN 1471-2164
R&D Projects: GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:60077344
Keywords : phosphatidylinositol 3-phosphate recognition * cutaneous leishmaniasis * insect trypanosomatids * heme-biosynthesis * lipophosphoglycan * alignment * gene * annotation * metabolism * enriettii * Whole genome sequencing * Leishmania (Mundinia) enriettii * L. (M.) macropodum * L. (M.) martiniquensis
OECD category: Microbiology
Impact factor: 3.594, year: 2019
Method of publishing: Open access
https://bmcgenomics.biomedcentral.com/track/pdf/10.1186/s12864-019-6126-y

Background: Trypanosomatids of the genus Leishmania are parasites of mammals or reptiles transmitted by bloodsucking dipterans. Many species of these flagellates cause important human diseases with clinical symptoms ranging from skin sores to life-threatening damage of visceral organs. The genus Leishmania contains four subgenera: Leishmania, Sauroleishmania, Viannia, and Mundinia. The last subgenus has been established recently and remains understudied, although Mundinia contains human-infecting species. In addition, it is interesting from the evolutionary viewpoint, representing the earliest branch within the genus and possibly with a different type of vector. Here we analyzed the genomes of L. (M.) martiniquensis, L. (M.) enriettii and L. (M.) macropodum to better understand the biology and evolution of these parasites.
Permanent Link: http://hdl.handle.net/11104/0304023