The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function

0518180 - ÚEM 2020 RIV GB eng J - Journal Article
Fawcett, James - Oohashi, T. - Pizzorusso, T.
The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function.
Nature Reviews Neuroscience. Roč. 20, č. 8 (2019), s. 451-465. ISSN 1471-003X. E-ISSN 1471-0048
R&D Projects: GA MŠMT(CZ) EF15_003/0000419
Institutional support: RVO:68378041
Keywords : chondroitin sulfate proteoglycans * long-term potentiation * central-nervous-system
OECD category: Neurosciences (including psychophysiology
Impact factor: 33.654, year: 2019
Method of publishing: Limited access
https://www.nature.com/articles/s41583-019-0196-3

Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan (CSPG)-containing structures that surround the soma and dendrites of various mammalian neuronal cell types. PNNs appear during development around the time that the critical periods for developmental plasticity end and are important for both their onset and closure. A similar structure - the perinodal ECM - surrounds the axonal nodes of Ranvier and appears as myelination is completed, acting as an ion-diffusion barrier that affects axonal conduction speed. Recent work has revealed the importance of PNNs in controlling plasticity in the CNS. Digestion, blocking or removal of PNNs influences functional recovery after a variety of CNS lesions. PNNs have further been shown to be involved in the regulation of memory and have been implicated in a number of psychiatric disorders.
Permanent Link: http://hdl.handle.net/11104/0303354