DNA repair capacity and response to treatment of colon cancer

0518156 - ÚEM 2020 RIV GB eng J - Journal Article
Vodička, Pavel - Vodenková, Soňa - Buchler, T. - Vodičková, Ludmila
DNA repair capacity and response to treatment of colon cancer.
Pharmacogenomics. Roč. 20, č. 17 (2019), s. 1225-1233. ISSN 1462-2416. E-ISSN 1744-8042
R&D Projects: GA MZd(CZ) NV15-27580A; GA ČR(CZ) GA18-09709S; GA MZd(CZ) NV18-03-00199
Institutional support: RVO:68378041
Keywords : colon cancer * DNA repair * DNA repair capacity
OECD category: Human genetics
Impact factor: 2.339, year: 2019
Method of publishing: Limited access
https://www.futuremedicine.com/doi/10.2217/pgs-2019-0070

DNA repair, a complex biological process, ensures genomic integrity. Alterations in DNA repair, occurring in many cancers, contribute to the accumulation of mutations in the genome, resulting in genomic instability and cancer progression. DNA repair also plays a substantial role in response to chemotherapeutics: rapidly dividing colon cancer cells, vulnerable to DNA-damaging agents and overcoming DNA repair, undergo cell death. DNA repair capacity represents a complex biomarker, integrating gene variants, gene expressions, the stability of gene products, the effect of inhibitors/stimulators, lifestyle and environmental factors. Here, we discuss DNA repair capacity in sporadic colon cancer, a frequent malignancy worldwide, in relation to tumor heterogeneity, prognosis and prediction, measurements in surrogate and target tissues and suggest important tasks to be addressed.
Permanent Link: http://hdl.handle.net/11104/0303331