Leukocyte telomere length is not affected by long-term occupational exposure to nano metal oxides

0517643 - ÚIACH 2020 RIV JP eng J - Journal Article
Hubáček, J. A. - Pelclová, D. - Dlouhá, D. - Mikuška, Pavel - Dvořáčková, Š. - Vlčková, Š. - Fenclová, Z. - Ondráček, J. - Koštejn, Martin - Schwarz, Jaroslav - Popov, A. - Křůmal, Kamil - Lánská, V. - Coufalík, Pavel - Zakharov, S. - Ždímal, Vladimír
Leukocyte telomere length is not affected by long-term occupational exposure to nano metal oxides.
Industrial Health. Roč. 57, č. 6 (2019), s. 741-744. ISSN 0019-8366. E-ISSN 1880-8026
R&D Projects: GA ČR(CZ) GBP503/12/G147; GA ČR(CZ) GA18-02079S
Institutional support: RVO:68081715 ; RVO:67985858
Keywords : telomere lenght * follow-up * metal nanoparticles
OECD category: Analytical chemistry; Public and environmental health (UCHP-M)
Impact factor: 1.471, year: 2019
Method of publishing: Open access
https://www.jstage.jst.go.jp/article/indhealth/57/6/57_2018-0146/_pdf

The aim of this study was to ascertain whether long-term occupational exposure to nanoparticles would affect relative leukocyte telomere length (LrTL). We analysed occupational exposure to size-resolved aerosol particles, with special emphasis on nanoparticles at two workshops: i/ the production of nanocomposites containing metal oxides, ii/ laboratory to test experimental exposure of nano-CuO to rodents. Thirty five exposed researchers (age 39.5 ± 12.6 yr, exposure duration 6.0 ± 3.7 yr) and 43 controls (40.4 ± 10.5 yr) were examined. LrTL did not significantly (p=0.14) differ between the exposed researchers (0.92 ± 0.13) and controls (0.86 ± 0.15). In addition, no significant correlation (r=−0.22, p=0.22) was detected between the duration of occupational exposure and LrTL. The results remained non-significant after multiple adjustments for age, sex and smoking status. Our pilot results suggest that relative leukocyte telomere length is not affected by occupational exposure to nanoparticles.
Permanent Link: http://hdl.handle.net/11104/0302955