Intralipid infusion in paediatric patient with quetiapine and lamotrigine intoxication

0517251 - ÚFCH JH 2020 RIV AT eng J - Journal Article
Klučka, J. - Juřenčák, T. - Kosinová, M. - Petr, Š. - Kratochvíl, M. - Sedláčková, Y. - Navrátil, Tomáš - Pelclová, D. - Jabandžiev, P.
Intralipid infusion in paediatric patient with quetiapine and lamotrigine intoxication.
Monatshefte fur Chemie. Roč. 150, č. 9 (2019), s. 1711-1714. ISSN 0026-9247. E-ISSN 1434-4475
Institutional support: RVO:61388955
Keywords : Antipsychotic drug intoxication * Life-threatening arrhythmia * Lipid resuscitation * Paediatric patient
OECD category: Physical chemistry
Impact factor: 1.349, year: 2019
Method of publishing: Limited access

We present a case of the acute intoxication of a 17-year-old patient after ingestion of 6 g of quetiapine in combination with 1 g of lamotrigine. Due to the severe tachycardia, hypertension, and prolonged QTc without improvement after standard treatment, the patient was treated with Intralipid 20% intravenous infusion recommended by the Toxicologic Information Centre. After lipid infusion, the QTc rapidly normalised and tachycardia resolved to sinus rhythm. The patient was transferred to psychiatry intensive care on the third day after admission.
Permanent Link: http://hdl.handle.net/11104/0302548