One-pot embedding of iron oxides and Gd(III) complexes into silica nanoparticles-morphology and aggregation effects on MRI dual contrasting ability

0511929 - FZÚ 2020 RIV NL eng J - Journal Article
Fedorenko, S. - Stepanov, A. - Zairov, R. - Kaman, Ondřej - Amirov, R. - Nizameev, I. - Kholin, K. - Ismaev, I. - Voloshina, A. - Sapunova, A. - Kadirov, M. - Mustafina, A.
One-pot embedding of iron oxides and Gd(III) complexes into silica nanoparticles-morphology and aggregation effects on MRI dual contrasting ability.
Colloids and Surfaces A-Physicochemical and Engineering Aspects. Roč. 559, Dec (2018), s. 60-67. ISSN 0927-7757. E-ISSN 1873-4359
Institutional support: RVO:68378271
Keywords : gadolinium complexes * silica nanoparticles * relaxivity * contrast agents * cytotoxicity
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 3.131, year: 2018
Method of publishing: Limited access
https://doi.org/10.1016/j.colsurfa.2018.09.044

The present work introduces one-pot synthetic route to join ultra-small iron oxides (6 nm) with Gd(III) complexes in small (∼30 nm) silica nanoparticles with high longitudinal and transverse relaxivity values (r1 = 34.7 mM-1 s-1 and r2 = 64.7 mM-1s-1 at 0.47 T). The design of the nanoparticles is based on the core-shell morphology, where the Gd(III) complexes were doped into the exterior silica layer. The doping mode is the reason for an efficient interfacial hydration and the small suppressing of r1 by iron oxides. The measurements on the whole body scanner at 1.5 T confirm the high contrasting abilities of T1 (Gd) and T2 (iron oxide) components in the nanoparticles.

Permanent Link: http://hdl.handle.net/11104/0302180