Number of the records: 1
Antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae
- 1.0511867 - ÚFCH JH 2020 RIV NL eng J - Journal Article
Marković, Z. M. - Kováčová, M. - Humpolíček, P. - Budimir, M. D. - Vajďák, J. - Kubát, Pavel - Mičušík, M. - Švajdlenková, H. - Danko, M. - Capáková, Z. - Lehocký, M. - Todorović Marković, B. M. - Špitalský, Z.
Antibacterial photodynamic activity of carbon quantum dots/polydimethylsiloxane nanocomposites against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae.
Photodiagnosis and Photodynamic Therapy. Roč. 26, JUN 2019 (2019), s. 342-349. ISSN 1572-1000. E-ISSN 1873-1597
R&D Projects: GA ČR(CZ) GA19-09721S
Grant - others:Ministerstvo školství, mládeže a tělovýchovy (MŠMT)(CZ) LO1504
Institutional support: RVO:61388955
Keywords : singlet oxygen generation * methylene-blue * antimicrobial activity * dots * light * nanoparticles * silicone * violet * Hydrophobic carbon quantum dots
OECD category: Physical chemistry
Impact factor: 2.894, year: 2019
Method of publishing: Limited access
Despite great efforts, the design of antibacterial surfaces is still a challenge. In this work, results of structural, mechanical, cytotoxic and antibacterial activities of hydrophobic carbon quantum dots/polydimethylsiloxane surfaces are presented. Antibacterial action of this surface is based on the generation of reactive oxygen species which cause bacteria damage by oxidative stress. At the same time, this surface was not cytotoxic towards the NIH/3T3 cells. Swelling-encapsulation-shrink method is applied for encapsulation of hydrophobic carbon quantum dots in medical grade silicone-polydimethylsiloxane. XPS and photoluminescence spectroscopy analyses confirm that hydrophobic carbon quantum dots have been encapsulated successfully into polydimethylsiloxane polymer matrix. Based on stress-strain test the improvement of mechanical properties of these nanocomposites is established. It is shown by electron paramagnetic resonance spectroscopy and luminescence method that nanocomposite generates singlet oxygen initiated by 470 nm blue light irradiation. Antibacterial testing shows the nanocomposite in the form of foil kills Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae and is very effective after only a 15 min irradiation.
Permanent Link: http://hdl.handle.net/11104/0302113
File Download Size Commentary Version Access 0511867.pdf 1 1.1 MB Publisher’s postprint require
Number of the records: 1