Genes and Mechanisms Responsible for Expansion of Acute Myeloid Leukaemia Blasts

0511732 - ÚMG 2020 RIV CZ eng J - Journal Article
Dvořák, Michal - Dvořáková, Marta
Genes and Mechanisms Responsible for Expansion of Acute Myeloid Leukaemia Blasts.
Folia Biologica. Roč. 65, č. 1 (2019), s. 11-23. ISSN 0015-5500. E-ISSN 0015-5500
R&D Projects: GA MŠMT LO1220
Institutional support: RVO:68378050
Keywords : hematopoietic stem-cell * internal tandem duplication * acute myelogenous leukemias * tet2 loss leads * transcription factor * self-renewal * lactic-acidosis * metabolic complication * complex karyotype * cohesin complex
OECD category: Biochemistry and molecular biology
Impact factor: 0.691, year: 2019
Method of publishing: Open access
https://fb.cuni.cz/volume-65-2019-no-1#articFB2019A0002

Acute myeloid leukaemia (AML) is the leading form of fatal acute leukaemia in adults. AML is a heterogeneous disease with respect to responsible mutations and chromosomal abnormalities as well as to their clinicopathological image. In recent years, great progress has been made in techniques allowing detection of genetic changes in both de novo AML and in secondary AML induced by other haematological disorders or therapy, and in detection of residual disease after therapy. Accumulated knowledge allowed better understanding of the molecules and mechanisms involved not only in the formation and expansion of a primary leukaemia-founding clone, but also of a temporal order of changes leading to the fully malignant phenotype. The recent knowledge of bone marrow (BM) compartments and interrelations among various BM resident and recruited cell types helps in understanding the AML development. The progress in the techniques and knowledge will result in the development and use of molecularly targeted therapies tailored to individual patient needs.
Permanent Link: http://hdl.handle.net/11104/0306726