Number of the records: 1
Proteins mimicking epitope of HIV-1 virus neutralizing antibody induce virus-neutralizing sera in mice
- 1.0511409 - BTÚ 2020 RIV GB eng J - Journal Article
Kosztyu, P. - Kuchař, Milan - Černý, Jiří - Barkocziova, L. - Malý, Michal - Petroková, Hana - Czerneková, L. - Lišková, Veronika - Kafková, L.R. - Knotigová, P. - Masek, J. - Turánek, J. - Malý, Petr - Raška, M.
Proteins mimicking epitope of HIV-1 virus neutralizing antibody induce virus-neutralizing sera in mice.
EBioMedicine. Roč. 47, SEP 2019 (2019), s. 247-256. ISSN 2352-3964. E-ISSN 2352-3964
R&D Projects: GA MZd(CZ) NV15-32198A; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:86652036
Keywords : Neutralizing antibody * Albumin-binding domain scaffold * Combinatorial protein library
OECD category: General and internal medicine
Impact factor: 5.736, year: 2019
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S2352396419304505?via%3Dihub
Background: The development of an effective vaccine preventing HIV-1 infection is hindered by the enormous antigenic variability and unique biochemical and immunological properties of HIV-1 Env glycoprotein, the most promising target for HIV-1 neutralizing antibody. Functional studies of rare elite neutralizers led to the discovery of broadly neutralizing antibodies.
Permanent Link: http://hdl.handle.net/11104/0301692
Number of the records: 1