Preferable adhesion of anti-epileptic drug on hydrogen terminated nanodiamonds: FTIR study

0511393 - FZÚ 2020 RIV SK eng C - Conference Paper (international conference)
Potocký, Štěpán - Štenclová, Pavla - Finsterle, T. - Pilarčíková, I. - Bláhová, I.A. - Ukraintsev, Egor - Stehlík, Štěpán - Kromka, Alexander - Nepovimová, E. - Musílek, K. - Kuča, K. - Rezek, B.
Preferable adhesion of anti-epileptic drug on hydrogen terminated nanodiamonds: FTIR study.
Conference Proceeding of 21st School of Vacuum Technology - Science Without Vacuum? Bratislava: Slovenská vákuová spoločnosť, 2019 - (Michalka, M.; Vincze, A.), s. 96-100. ISBN 978-80-99905-01-7.
[School of Vacuum Technology - Science Without Vacuum? /21./. Štrbské Pleso (SK), 01.10.2019-04.10.2019]
R&D Projects: GA MŠMT(CZ) EF16_019/0000760; GA ČR(CZ) GA17-19968S
Grant - others:OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Institutional support: RVO:68378271
Keywords : nanodiamond * FTIR * phenytoin * surface termination
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)

The usage of Fourier infrared spectroscopy for studies of preferable analyte adhesion is demonstrated on anti-epileptic drug and selectively terminated nanodiamonds combined with gold nanoparticles. The gold mirrors used as suitable substrates for IR spectroscopy are further substituted by interdigitated microelectrodes for electrical sensing. The results showed selectiveness of the phenytoin drug bond to differently terminated nanodiamonds where strong IR signal corresponding to the drug is detected on H-terminated nanodiamonds. Addition of gold NPs results to decrease of the signal corresponding to the drug. When O-terminated nanodiamonds with/without gold nanoparticles were used no evident drug signal was detected.

Permanent Link: http://hdl.handle.net/11104/0301670