Developmental and sex differences in cardiac tolerance to ischemia-reperfusion injury: the role of mitochondria

0508598 - FGÚ 2020 RIV CA eng J - Journal Article
Ošťádal, Bohuslav - Drahota, Zdeněk - Houštěk, Josef - Milerová, Marie - Ošťádalová, Ivana - Hlaváčková, Markéta - Kolář, František
Developmental and sex differences in cardiac tolerance to ischemia-reperfusion injury: the role of mitochondria.
Canadian Journal of Physiology and Pharmacology. Roč. 97, č. 9 (2019), s. 808-814. ISSN 0008-4212. E-ISSN 1205-7541
R&D Projects: GA ČR(CZ) GA18-03461S; GA ČR(CZ) GJ19-04790Y
Institutional support: RVO:67985823
Keywords : neonatal heart * female heart * ischemia-reperfusion injury * cardiac ischemic tolerance * mitochondrial permeability transition pore * calcium-induced swelling
OECD category: Physiology (including cytology)
Impact factor: 1.946, year: 2019
Method of publishing: Limited access
https://www.nrcresearchpress.com/doi/10.1139/cjpp-2019-0060#.XljPJKhKiUk

Age and sex play an essential role in the cardiac tolerance to ischemia-reperfusion injury: cardiac resistance significantly decreases during postnatal maturation and the female heart is more tolerant than the male myocardium. It is widely accepted that mitochondrial dysfunction, and particularly mitochondrial permeability transition pore (MPTP) opening, plays a major role in determining the extent of cardiac ischemia-reperfusion injury. We have observed that the MPTP sensitivity to the calcium load differs in mitochondria isolated from neonatal and adult myocardium, as well as from adult male and female hearts. Neonatal and female mitochondria are more resistant both in the extent and in the rate of mitochondrial swelling induced by high calcium concentration. Our data further suggest that age-and sex-dependent specificity of the MPTP is not the result of different amounts of ATP synthase and cyclophilin D: neonatal and adult hearts, similarly as the male and female hearts, contain comparable amounts of MPTP and its regulatory protein cyclophilin D. We can speculate that the lower sensitivity of MPTP to the calcium-induced swelling may be related to the higher ischemic tolerance of both neonatal and female myocardium.
Permanent Link: http://hdl.handle.net/11104/0299460