Bi-Modal nonlinear optical contrast from Si nanoparticles for cancer theranostics

0507967 - FZÚ 2020 RIV DE eng J - Journal Article
Kharin, A.Y. - Lysenko, V.V. - Rogov, A. - Ryabchikov, Yury V. - Geloen, A. - Tishchenko, I. - Marty, O. - Sennikov, P.G. - Kornev, R.A. - Zavestovskaya, I.N. - Kabashin, A.V. - Timoshenko, V.Y.
Bi-Modal nonlinear optical contrast from Si nanoparticles for cancer theranostics.
Advanced Optical Materials. Roč. 7, č. 13 (2019), s. 1-8, č. článku 1801728. ISSN 2195-1071. E-ISSN 2195-1071
R&D Projects: GA MŠMT EF15_003/0000445; GA MŠMT LO1602
Grant - others:OP VVV - BIATRI(XE) CZ.02.1.01/0.0/0.0/15_003/0000445
Institutional support: RVO:68378271
Keywords : nonlinear bioimaging * second harmonic generation * silicon nanoparticles * two-photon luminescence
OECD category: Optics (including laser optics and quantum optics)
Impact factor: 8.286, year: 2019
Method of publishing: Limited access
https://doi.org/10.1002/adom.201801728

Presenting a safe alternative to conventional compound quantum dots and other functional nanostructures, nanosilicon can offer a series of breakthrough hyperthermia‐based therapies under near‐infrared, radiofrequency, ultrasound, etc., excitation, but the size range to sensitize these therapies is typically too large (>10 nm) to enable efficient imaging functionality based on photoluminescence properties of quantum‐confined excitonic states. Here, it is shown that large Si nanoparticles (NPs) are capable of providing two‐photon excited luminescence (TPEL) and second harmonic generation (SHG) responses, much exceeding that of smaller Si NPs, which promises their use as probes for bi‐modal nonlinear optical bioimaging. It is finally demonstrated that the combination of TPEL and SHG channels makes possible efficient tracing of both separated Si NPs and their aggregations in different cell compartments, while the resolution of such an approach is enough to obtain 3D images.
Permanent Link: http://hdl.handle.net/11104/0298931