Blind deconvolution estimation of an arterial input function for small animal DCE-MRI

0507813 - ÚPT 2020 RIV US eng J - Journal Article
Jiřík, Radovan - Taxt, T. - Macíček, Ondřej - Bartoš, Michal - Kratochvíla, Jiří - Souček, Karel - Dražanová, Eva - Krátká, Lucie - Hampl, A. - Starčuk jr., Zenon
Blind deconvolution estimation of an arterial input function for small animal DCE-MRI.
Magnetic Resonance Imaging. Roč. 62, OCT (2019), s. 46-56. ISSN 0730-725X. E-ISSN 1873-5894
R&D Projects: GA ČR(CZ) GA16-13830S; GA MŠMT ED0017/01/01; GA MŠMT(CZ) LO1212; GA MŠMT(CZ) EF16_013/0001775
Institutional support: RVO:68081731 ; RVO:67985556 ; RVO:68081707
Keywords : DCE-MRI * blind deconvolution * arterial input function
OECD category: Medical laboratory technology (including laboratory samples analysis; Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8) (UTIA-B); Medical laboratory technology (including laboratory samples analysis (BFU-R)
Impact factor: 2.053, year: 2019
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0730725X18306763?via%3Dihub

Purpose: One of the main obstacles for reliable quantitative dynamic contrast-enhanced (DCE) MRI is the need for accurate knowledge of the arterial input function (AIF). This is a special challenge for preclinical small animal applications where it is very difficult to measure the AIF without partial volume and flow artifacts. Furthermore, using advanced pharmacokinetic models (allowing estimation of blood flow and permeability-surface area product in addition to the classical perfusion parameters) poses stricter requirements on the accuracy and precision of AIF estimation. This paper addresses small animal DCE-MRI with advanced pharmacokinetic models and presents a method for estimation of the AIF based on blind deconvolution. Methods: A parametric AIF model designed for small animal physiology and use of advanced pharmacokinetic models is proposed. The parameters of the AIF are estimated using multichannel blind deconvolution. Results: Evaluation on simulated data show that for realistic signal to noise ratios blind deconvolution AIF estimation leads to comparable results as the use of the true AIF. Evaluation on real data based on DCE-MRI with two contrast agents of different molecular weights showed a consistence with the known effects of the molecular weight. Conclusion: Multi-channel blind deconvolution using the proposed AIF model specific for small animal DCE-MRI provides reliable perfusion parameter estimates under realistic signal to noise conditions.
Permanent Link: http://hdl.handle.net/11104/0298781