Surface plasmon resonance biosensor for the ultrasensitive detection of bisphenol A

0507808 - ÚFE 2020 RIV DE eng J - Journal Article
Chadtová Song, Xue - Gedeonová, Erika - Homola, Jiří
Surface plasmon resonance biosensor for the ultrasensitive detection of bisphenol A.
Analytical and Bioanalytical Chemistry. Roč. 411, č. 22 (2019), s. 5655-5658. ISSN 1618-2642. E-ISSN 1618-2650
R&D Projects: GA MZd(CZ) NV16-27611A
Institutional support: RVO:67985882
Keywords : Surface plasmon resonance biosensor * Bisphenol A * Functionalized gold nanoparticles
OECD category: Analytical chemistry
Impact factor: 3.637, year: 2019
Method of publishing: Limited access
https://link.springer.com/article/10.1007%2Fs00216-019-01996-8

Bisphenol A (BpA) is a chemical that is extensively used in common plastic products, such as food and drink containers. It can leach from the plastics and penetrate into the human body, where it acts as an endocrine disruptor with significant risks to human health. In order to minimize the exposure of human populations to BpA, methods for the detection of BpA are needed. In this work, we present a novel surface plasmon resonance (SPR) biosensor for ultrasensitive detection of BpA. Our approach combines a binding inhibition assay with functionalized gold nanoparticles for the enhancement of sensor response. We demonstrate that the developed biosensor enables the detection of BpA in a wide range of concentrations (0.01 to 100,000 ng/mL) with an extremely low limit of detection—5.2 pg/mL.
Permanent Link: http://hdl.handle.net/11104/0298776