Genome-wide recruitment profiling of transcription factor Crz1 in response to high pH stress

0507583 - ÚMG 2020 RIV US eng J - Journal Article
Roque, A. - Petrezselyova, Silvia - Serra-Cardona, A. - Ariňo, J.
Genome-wide recruitment profiling of transcription factor Crz1 in response to high pH stress.
BMC Genomics. Roč. 17, August (2016), č. článku 662. ISSN 1471-2164. E-ISSN 1471-2164
Institutional support: RVO:68378050
Keywords : Alkaline pH stress * Calcineurin signaling * Crz1 recruitment * Consensus binding sequence * Saccharomyces cerevisiae
OECD category: Biochemistry and molecular biology
Impact factor: 3.729, year: 2016
Method of publishing: Open access
https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-016-3006-6

Background: Exposure of the budding Saccharomyces cerevisiae to an alkaline environment produces a robust transcriptional response involving hundreds of genes. Part of this response is triggered by an almost immediate burst of calcium that activates the Ser/Thr protein phosphatase calcineurin. Activated calcineurin dephosphorylates the transcription factor (TF) Crz1, which moves to the nucleus and binds to calcineurin/Crz1 responsive gene promoters. In this work we present a genome-wide study of the binding of Crz1 to gene promoters in response to high pH stress.
Permanent Link: http://hdl.handle.net/11104/0298575